Most often resolving problems with opening ND5 files is very simple. Just install an appropriate program that supports such files. All of the listed programs support ND5 files, but may vary in offered function and purpose. Some programs may be capable only of viewing contents of ND5 files or offer file conversion options, but may not be capable of editing such files.
It is possible that although a compatible program has been installed on user’s system, it is not used by the system to open it. This may happen because no default application was associated with this type of files. To associate ND5 files with given application, select "Open with" from drop-down menu (accessed by right-clicking on the file). Then select from the list the program or application you want to be used to open this type of file. If the DeSmuME applications is not on the list, select "Browse" option in order to manually locate the directory where DeSmuME has been installed.
Sometimes problems with opening ND5 files may not lie with the application itself, but can arise due to other causes, such as: