The file extension MPE generally identifies video data in MPEG format. Mpe file contain both video and audio data and mainly use the MPEG-1 and MPEG-2 compression.
In principle, most video players and editing programs should be able to handle MPE files. If the extension MPE is not recognized or it does not appear in the file selection, changing the extension to mpg can help.
Most often resolving problems with opening MPE files is very simple. Just install an appropriate program that supports such files. All of the listed programs support MPE files, but may vary in offered function and purpose. Some programs may be capable only of viewing contents of MPE files or offer file conversion options, but may not be capable of editing such files.
It is possible that although a compatible program has been installed on user’s system, it is not used by the system to open it. This may happen because no default application was associated with this type of files. To associate MPE files with given application, select "Open with" from drop-down menu (accessed by right-clicking on the file). Then select from the list the program or application you want to be used to open this type of file. If the QuickTime Player applications is not on the list, select "Browse" option in order to manually locate the directory where QuickTime Player has been installed.
Sometimes problems with opening MPE files may not lie with the application itself, but can arise due to other causes, such as: